Thyroid and Antithyroid Agents is part of the Endocrine System section of Pharmacology. Practise 25 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Thyroid and Antithyroid Agents MCQs track levothyroxine conversion to triiodothyronine, cautious dosing in older adults, iodide preparation for surgery and Hashimoto progression. These high-yield NEET PG questions on hypo- and hyperthyroidism pharmacology.
Sample Thyroid and Antithyroid Agents MCQs with answers
Sample MCQ #1
Which of the following is a sign or symptom that would be expected to occur in the event of chronic overdose with exogenous T4?
ABradycardia
Bscalely skin
CLethargy, sleepiness
DWeight loss
Show Answer & Explanation ▾
✓ Correct Answer: D. Weight loss
In hyperthyroidism, the metabolic rate increases, and even though there is increased appetite, weight loss often occurs. The other choices are symptoms seen in hypothyroidism. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg. no. 690
Sample MCQ #2
A 34-year-old woman underwent near total thyroidectomy. She was started on levothyroxine. What hormone is produced in the peripheral tissues when levothyroxine is administered?
AT3
BT4
CTSH
DFSH
Show Answer & Explanation ▾
✓ Correct Answer: A. T3
L-thyroxine (levothyroxine, a synthetic form of T4) is peripherally converted to T3 (biologically active) and rT3 (biologically inactive), Indicated in Myxedema & Hypothyroidism. Side effects are Sweating, heat intolerance Tachycardia, palpitations, arrhythmias, chest pain Tremors Weight loss (this drug is sometimes misused by patients trying to lose weight) Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg. no. 694
Sample MCQ #3
Initiating T4 therapy for an elderly patient with long- standing hypothyroidism, is it important to begin with small doses to avoid which of the following?
AFlare-up of exophthalmos
BSeizures
CHemolysis
DOverstimulation of the heart
Show Answer & Explanation ▾
✓ Correct Answer: D. Overstimulation of the heart
Patients with long-standing hypothyroidism, especially those who are elderly, are highly sensitive to the stimulatory effects of T4 on cardiac function. Administration of regular doses can cause overstimulation of the heart and cardiac collapse Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg. no. 689
Sample MCQ #4
A 65-year-old woman with MNG is scheduled for total thyroidectomy. Which of the following drugs will be administered for 10-14 days before surgery to reduce the vascularity of his thyroid gland?
ALevothyroxine
BLugol's solution
CPrednisone
DRadioactive iodine
Show Answer & Explanation ▾
✓ Correct Answer: B. Lugol's solution
Iodides inhibit the synthesis and release of thyroid hormone and decrease the size and vascularity of the hyperplastic gland. Lugol’s solution contains a mixture of potassium iodide and iodine. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg. no. 695
Sample MCQ #5
A 73-year-old woman is brought to you for progressive memory loss She has gained 10kgs in the last year. Her father died from complications of Alzheimer disease. She is oriented but has short-term memory deficits. Examination shows a normal gait and delayed relaxation of the achilles reflex bilaterally. Her skin is dry and she has brittle nails. Treatment with which of the following is most appropriate?
AThiamine
BVitamin B12
CRivastigmine
DL-thyroxine
Show Answer & Explanation ▾
✓ Correct Answer: D. L-thyroxine
Hashimoto thyroiditis is characterized by progressive destruction of thyroid tissue by antithyroid peroxidase antibodies and antithyroglobulin antibodies. Initially, it may manifest with transient hyperthyroidism, before progressing to hypothyroidism. Hypothyroidism results in a generalized decrease of the basal metabolic rate, which can present with weight gain, fatigue, dry skin and brittle nails, along with concentration and memory impairment. Treatment with Life-long oral administration of L-thyroxine (T4) , commence at a lower and more slow-acting dose with increasing severity of hypothyroidism because of the risk of cardiac side effects. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg. no. 699
Sample MCQ #6
A 45-year-old woman is on L-thyroxine therapy for 2 years with adequate therapeutic response. However, with all of the following drugs, dose of L-thyroxine is to be increased except?
APropranolol
BPrednisone
COCP
DOmeprazole
Show Answer & Explanation ▾
✓ Correct Answer: B. Prednisone
Increased dosage necessary Estrogen & SERM (Increase TBG in the serum) Bile acid-binding resins Omeprazole Calcium carbonate (Reduces absorption of thyroid hormone) Phenytoin Carbamazepine (Increases metabolism of thyroid hormones) Propranolol (Reduces conversion of T4 to T3) Reduced dosage necessary: glucocorticoids (Decrease TBG in the serum) Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg. no. 704
What you can practise in Thyroid and Antithyroid Agents
25 Thyroid and Antithyroid Agents MCQs on Thyroid, Antithyroid Agents, Endocrine System — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
Progress and performance tracking to measure retention
What do Thyroid and Antithyroid Agents MCQs cover?
Thyroid and Antithyroid Agents MCQs track levothyroxine conversion to triiodothyronine, cautious dosing in older adults, iodide preparation for surgery and Hashimoto progression. These high-yield NEET PG questions on hypo- and hyperthyroidism pharmacology.
How many Thyroid and Antithyroid Agents questions are there, and which exams do they cover?
MedLadder includes 25 curated MCQs for Thyroid and Antithyroid Agents under Pharmacology (Endocrine System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
