Anti-leprosy Drugs is part of the Antimicrobials section of Pharmacology. Practise 8 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Anti-leprosy Drugs MCQs test multidrug therapy under the national programme, supervised rifampicin and clofazimine dosing, and corticosteroids for lepra reactions. These high-yield NEET PG questions on tuberculoid disease, skin lesions and treatment duration.
Sample Anti-leprosy Drugs MCQs with answers
Sample MCQ #1
A patient presented with a few hypoesthetic, hairless skin plaques. Diagnosis of leprosy confirmed with tissue biopsy. What is the mechanism of action of drugs used to treat this condition? i) Inhibit dihydropteroate synthase ii) Inhibit DNA-dependent RNA polymerase iii) binding preferentially to mycobacterial DNA and inhibiting replication and growth
Ai)
Bi), ii)
Ci), ii), iii)
Di), iii)
Show Answer & Explanation ▾
✓ Correct Answer: B. i), ii)
Patient is having presentation of Tuberculoid leprosy. Treatment of tuberculoid leprosy is dapsone and rifampin. Mechanism of action of dapsone and rifampin are inhibit dihydropteroate synthase and Inhibit DNA-dependent RNA polymerase respectively. Lepromatous—presents diffusely over the skin, with leonine (lion-like) facies, and is communicable (high bacterial load); characterized by low cell-mediated immunity with a humoral Th2 response. Tuberculoid—limited to a few hypo esthetic, hairless skin plaques; characterized by high cell mediated immunity with a largely Th1-type immune response and low bacterial load. Treatment: dapsone and rifampin for tuberculoid form; clofazimine is added for lepromatous form. Reference: First Aid Step 1 USMLE 18 th edition Page no. 141
Sample MCQ #2
Which of the following drug given supervised as per national leprosy elimination programme? i) Rifampicin 600 mg once a month ii) Clofazimine 300 mg once a month iii) Dapsone 100 mg daily iv) Clofazimine 50 mg daily
Ai), ii), iii), iv)
Bi), ii), iii)
Ci), ii)
Di)
Show Answer & Explanation ▾
✓ Correct Answer: C. i), ii)
Under NLEP Rifampicin and Clofazimine are given under supervision for both Multibacillary and Paucibacillary Leprosy. Rifampicin is given 600 mg once a month under supervision. Clofazimine is given 300 mg once a month under supervision and 50 mg daily unsupervised for 28 days. Dapsone is given 100 mg once daily unsupervised for 28 days. Multibacillary Leprosy is treated for 12 months and Paucibacillary Leprosy for 6 months. Under RNTCP, DOTS: Rifampicin, Isoniazid, Pyrazinamide and Ethambutol are administered under supervision. REFERENCE: KD TRIPATHI Essential of Medical Pharmacology 7 th Edition Page no. 780-786
Sample MCQ #3
Type 1 & 2 lepra reaction treated with?
ACorticosteroid
BDapsone
CMinocycline
DRifampicin
Show Answer & Explanation ▾
✓ Correct Answer: A. Corticosteroid
Treatment of choice for type 1 as well as type 2 lepra reaction is corticosteroids. For severe reaction, prednisolone 40-60mg/day is started immediately and continued till the reaction subsides. The dose is then tapered over 2-3 months. For resistant cases of Erythema nodosum leprosum drug of choice is thalidomide. REFERENCE: KD TRIPATHI Essential of Medical Pharmacology 7 th Edition page no. 780-786
What you can practise in Anti-leprosy Drugs
8 Anti-leprosy Drugs MCQs on Antimicrobials — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
Progress and performance tracking to measure retention
Anti-leprosy Drugs MCQs test multidrug therapy under the national programme, supervised rifampicin and clofazimine dosing, and corticosteroids for lepra reactions. These high-yield NEET PG questions on tuberculoid disease, skin lesions and treatment duration.
How many Anti-leprosy Drugs questions are there, and which exams do they cover?
MedLadder includes 8 curated MCQs for Anti-leprosy Drugs under Pharmacology (Antimicrobials), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
