Skin Pathology MCQs

Actinic keratosis may show dysplastic changes that lead to cutaneous SCC. The stratum corneum is thickened (hyperkeratosis) and cells in this layer retain their nuclei (parakeratosis). Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1145

Lymphocytic infiltrates may be seen in superficial dermis. Release of melanin from dead nevus cells into dermis may occur (melanin incontinence) and this is phagocytosed by dermal macrophages leading to a peculiar fibrosis surrounding epidermal rete ridges that are involved by nevus. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1137

At the deepest extent of melanocytic nevi, nevus cells often acquire fusiform contours and grow in fascicles resembling neural tissue, this phenomenon is called neurotization and it is absent in melanoma. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1136

FAMMM is an autosomal dominant syndrome characterized by multiple dysplastic nevi and melanomas and in 50% cases melanomas develop by the age of 60. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1137

It is calculated from top of granular layer to deepest intradermal cells if overlying skin is intact, if ulcerated start from base of ulcer. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1135

There is overexpression of PDGF beta due to translocation involving genes encoding collagen 1A1 (COL1A1) and platelet-derived growth factor-beta (PDGFB), so tyrosine kinase inhibitors are used. Although they are locally aggressive and can recur, they rarely metastasize, metastasis is seen with tumors that exhibit greater cytologic atypia. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1150

Multiple small seborrheic keratosis on face are termed as dermatosis papulosa nigra. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 25, pg 1158

Mycosis fungoides is the most common form of a type of blood cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells , become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions. Reference : Robbins Basic Pathology, 8 th edition, page number - 616