Developmental Disorders, Infections and Tumors of Bone is part of the Bone and Musculoskeletal System section of Pathology. Practise 18 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Developmental Disorders, Infections and Tumors of Bone MCQs range from the sunray periosteal reaction of osteosarcoma and GNAS-driven McCune-Albright syndrome to haematogenous osteomyelitis of the metaphysis and steroid-related bone infarction. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
Lumbar spine > Proximal femur > Pelvis > Thoracic spine > Ribs Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 977
Answer- D. All Infection :- Osteomyelitis, Brodie's abscess, syphilis Neoplasms Benign : Osteoid osteoma Malignant : Ewing's sarcoma, osteosarcoma Eosinophilic granuloma Healed stress fracture Hypertrophic pulmonary osteoarthropathy
The mutation of guanine nucleotide-activating alpha subunit (GNAS) gene is the somatic mutation related to the McCune-Albright syndrome. GNAS mutation is also detected in about 30% to 40% of sporadic growth hormone (GH) secreting tumors.
C i.e. Osteogenic Sarcoma Sunray appearance is classically seen in osteosarcoma. It may also occur in metastases, Ewings sarcoma, Haemang oma, Meningioma and tuberculosis.
Infarction of bone and marrow is relatively common. It can be limited to the medullary cavity or involve both the medulla and cortex. Fractures and corticosteroid administration are the two most common causes. Microscopically, dead bone is characterized by empty lacunae surrounded by necrotic adipocytes. The released fatty acids bind calcium and form insoluble calcium soaps. The remaining trabeculae act as scaffolding for deposition of new bone, while osteoclasts resorb necrotic trabeculae. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, chapter 26, pg 1185
Hematogenous osteomyelitis primarily affects the metaphyseal area of the long bones (knee, ankle, hip) because of the unique vascular supply in this region. Normally, arterioles enter the calcified portion of the growth plate, form a loop, and then drain into the medullary cavity without establishing a capillary bed. This vascular loop permits slowing and sludging of blood flow, allowing bacteria time to penetrate the walls of the blood vessels and establish an infective focus within the bone marrow. Osteomyelitis may break into the periosteum (choice e) but does not originate there. Vascular loops do not reach the epiphysis (choice c). Choices a and b would be distinctly uncommon. Reference :Robbins & Cotran Pathologic Basis of Diseases 10 th edition , chapter 26, pg 1171
Developmental Disorders, Infections and Tumors of Bone MCQs range from the sunray periosteal reaction of osteosarcoma and GNAS-driven McCune-Albright syndrome to haematogenous osteomyelitis of the metaphysis and steroid-related bone infarction. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
MedLadder includes 18 curated MCQs for Developmental Disorders, Infections and Tumors of Bone under Pathology (Bone and Musculoskeletal System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
