Renal Tumors MCQs

Ans. is 'a' i.e., Histopathology Anaplastic nuclear change is the only criterion of "unfavourable" histology in Wilm's tumor and all Wilm's tumor lacking this feature are designated as having "favourable histology". Anaplastic nuclear change reflects extreme polypoidy & is usually apparent under low magnification. "Anaplastic histology remains a critical determinant of adverse prognosis. Even anaplasia restricted to kidney confers an increased risk of recurrence & death, underscoring the need for correctly identifying this histologic features."

The familial variants of renal cell carcinomas are: Von Hipple landau (VHL) syndrome Hereditory leiomyomatosis Hereditary papillary carcinomas Birt hogg dube syndrome Hemihypertrophy, also referred to as hemihyperplasia, is a condition in which one side of the body or a part of one side of the body is larger than the other. hemihypertrophy is related to several congenital syndromes including beckwith-wiedemann syndrome and russell-silver syndrome. Reference : Robbins Basic Pathology, 9 th edition, Page- 953

Wilms tumour, or nephroblastoma, is the most common primary tumour of the kidney in children, with most cases occurring in children between 2 and 5 years of age. Three groups of congenital malformations are associated with an increased risk for Wilms tumour. These are WAGR syndrome (i.e., Wilms tumour, aniridia, genital abnormalities, and mental retardation); Denys-Drash syndrome (DDS), and Beckwith-Wiedemann syndrome (BWS). On microscopic examination, Wilms tumours are characterized by recognizable attempts to recapitulate different stages of nephrogenesis.The classic triphasic combination of blastemal, stromal, and epithelial cell types is observed in most lesions, although the percentage of each component is variable. Reference : Robbins Basic Pathology, 10th edition, Page- 289-90