Glomerular Diseases is part of the Genitourinary System section of Pathology. Practise 54 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Glomerular Diseases MCQs move through IgA nephropathy with post-infective haematuria, the permeability defect of nephrotic syndrome, FSGS immunofluorescence, and the linear deposits of Goodpasture disease. This is high-yield NEET PG nephrology for FMGE, INI-CET and NEET SS.
Sample Glomerular Diseases MCQs with answers
Sample MCQ #1
A 35-year-old man complains of recurrent hematuria since his youth. The hematuria typically occurs following upper respiratory tract infections. Vital signs are normal. Urinalysis shows proteinuria, hematuria, and a few red blood cell casts. Laboratory studies disclose normal levels of BUN and creatinine. The ANA and ANCA tests are negative. Which of the characteristic findings that leads to diagnosis of disease is:
APredominantly deposition on IgG in mesangium
BPredominantly deposition on IgG in Subendothelial
CPredominantly deposition on IgA in Subendothelium
DPredominantly deposition on IgA in mesangium
Show Answer & Explanation ▾
✓ Correct Answer: D. Predominantly deposition on IgA in mesangium
IgA nephropathy (Berger Disease)- IgA nephropathy, characterized by the presence of prominent IgA deposits in the mesangial regions and recurrent hematuria, is the most common type of glomerulonephritis worldwide. Reference: Robbins 10th Ed pg 922
Sample MCQ #2
Which is the most common mechanism leads to edema in nephrotic syndrome?
ANa+ and water restriction
BIncreased venous pressure
CDecreased serum albumin
DDecreased fibrinogen
Show Answer & Explanation ▾
✓ Correct Answer: C. Decreased serum albumin
Nephrotic syndrome is the most important cause of albumin loss from the blood. In diseases that are characterized by nephrotic syndrome, the glomerular capillaries become leaky, leading to the loss of albumin (and other plasma proteins) in the urine and the development of generalized edema. Reference: Robbins and Cotran Pathologic Basis of Diseases, 10ᵗʰ ed Pg:99
Sample MCQ #3
A 17-year-old female patient presented with facial puffiness. Physical examination revealed edema. Laboratory findings revealed creatinine of 3.8 mg/dL along with proteinuria. A differential diagnosis of nephrotic syndrome was made. All of these metabolic findings will be seen in this patient; except:
AHypoalbuminemia
BHyperlipidemia
CLoss of anticoagulant
DLoss of fibrinogen
Show Answer & Explanation ▾
✓ Correct Answer: D. Loss of fibrinogen
Nephrotic syndrome is caused by a derangement in glomerular capillary walls resulting in increased permeability to plasma proteins. The manifestations of the syndrome include, Massive proteinuria, Hypoalbuminemia, hyperlipidemia, lipiduria along with loss of anticoagulants. Due to low albumin levels, fibrinogen and vWD levels are raised. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition Chapter 20, pg 909
Sample MCQ #4
Which of the following would immunofluorescence staining of the kidney with Focal segmental glomerulosclerosis most likely reveal?
AIgG positivity with a granular pattern
BIgG and IgM positivity with a granular pattern
CIgG positivity with a linear pattern
DEntrapped IgM
Show Answer & Explanation ▾
✓ Correct Answer: D. Entrapped IgM
FSGS has entrapped IgM and C3 noted by immunofluorescence staining. IgG positivity with a granular pattern is seen in membranous glomerulonephropathy, IgG and IgM positivity in postinfectious glomerulonephritis, and IgG positivity with a linear pattern in type I rapidly progressive glomerulonephritis. IgM positivity with a linear pattern is not normally described in diseases of the kidney. Reference : Robbins Basic Pathology, 10 th edition, Page- 556
Sample MCQ #5
A patient presenting with haemoptysis and renal failure with anti-basement membrane antibodies positives on renal biopsy. What is your diagnosis?
AGood pasture's syndrome
BWegener's granulomatosis
CChurg Strauss disease
DHenoch-scholein purpura
Show Answer & Explanation ▾
✓ Correct Answer: A. Good pasture's syndrome
Anti-GBM antibody-mediated crescentic GN (Goodpasture disease) is characterized by linear deposits of IgG and, in many cases, C3 in the GBM. In some patients, the anti-GBM antibodies also bind to pulmonary alveolar capillary basement membranes to produce the clinical picture of pulmonary hemorrhages associated with renal failure. These patients are said to have Goodpasture syndrome. Anti-GBM antibodies are present in the serum and are helpful in diagnosis. It is important to recognize anti-GBM antibody-mediated crescentic GN, because affected individuals benefit from plasmapheresis, which removes pathogenic antibodies from the circulation. Reference : Robbins Basic Pathology, 10th edition, Page- 562-563
Sample MCQ #6
56 year old female presents with breast carcinoma, She started presenting with froathy urine. What is most common nephropathy in these cases
AMembranous nephropathy
BMPGN
CRPGN
DMinimal change disease
Show Answer & Explanation ▾
✓ Correct Answer: A. Membranous nephropathy
The most common nephropathy in malignancy is membranous nephropathy . Reference : Robbins Basic Pathology, 10 th edition, Page- 558
What you can practise in Glomerular Diseases
54 Glomerular Diseases MCQs on Genitourinary System — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
Progress and performance tracking to measure retention
Glomerular Diseases MCQs move through IgA nephropathy with post-infective haematuria, the permeability defect of nephrotic syndrome, FSGS immunofluorescence, and the linear deposits of Goodpasture disease. This is high-yield NEET PG nephrology for FMGE, INI-CET and NEET SS.
How many Glomerular Diseases questions are there, and which exams do they cover?
MedLadder includes 54 curated MCQs for Glomerular Diseases under Pathology (Genitourinary System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
