Male Genital Tract is part of the Genitourinary System section of Pathology. Practise 32 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Male Genital Tract MCQs cover germ cell neoplasia in situ and its markers, from PLAP-positive seminoma to OCT3/4 embryonal carcinoma, isochromosome 12p, prostate ETS rearrangements, and Gleason grading. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
Sample Male Genital Tract MCQs with answers
Sample MCQ #1
Which is not a germ cell tumor derived from germ cell neoplasia in situ
ASpermatocytic tumor
BSeminoma
CEmbryonal carcinoma
DChoriocarcinoma
Show Answer & Explanation ▾
✓ Correct Answer: A. Spermatocytic tumor
Germ cell neoplasia in situ is a precursor lesion found in association with 90% of germ cell neoplasms and with every type of GCT except spermatocytic tumor and unusual types that arise in infancy. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
Sample MCQ #2
On IHC seminoma cell is positive for
AOCT3/4
BKIT
CPodoplanin
DAll the above
Show Answer & Explanation ▾
✓ Correct Answer: D. All the above
Seminoma cells are negative for cytokeratin. Placental alkaline phosphatase (PLAP) is also positive in seminoma Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
Sample MCQ #3
Teratoma with somatic type malignant transformation can lead to
ASCC
BAdenocarcinoma
CSarcoma
DAll the above
Show Answer & Explanation ▾
✓ Correct Answer: D. All the above
Rarely malignant non-germ cell tumors arise in post-pubertal teratomas, a phenomenon referred to as teratoma with somatic type malignant transformation. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
Sample MCQ #4
Most common genetic alteration in prostate cancer
AChromosomal rearrangement that juxtaposes ETS next to TMPRSS2
BMYC amplification
CSilencing of p27 gene
DLoss of TP53
Show Answer & Explanation ▾
✓ Correct Answer: A. Chromosomal rearrangement that juxtaposes ETS next to TMPRSS2
All these alterations are seen in prostate cancer, but chromosomal rearrangement that juxtaposes coding sequence of ETS family transcriptor gene next to androgen-regulated TMPRSS2 promoter is the most common of these, such that ETS oncogene is overexpressed in an androgenic fashion. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 977
Sample MCQ #5
False statement about embryonal carcinoma
AMore aggressive than seminoma
BPleomorphism is seen within tumor cells
CVascular-lymphatic invasion is common
DTumor cells are negative for OCT3/4
Show Answer & Explanation ▾
✓ Correct Answer: D. Tumor cells are negative for OCT3/4
Tumor cells are positive for OCT3/4 and cytokeratin, and negative for KIT and podoplanin. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
Sample MCQ #6
Reduplication of which chromosome is found invariably in invasive GCTs regardless of histologic subtype
A13p
B17p
C12p
D10p
Show Answer & Explanation ▾
✓ Correct Answer: C. 12p
Isochromosome 12p, a cytogenetic alteration that is invariably in invasive GCTs regardless of histologic subtype. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
Sample MCQ #7
Gleason grade group 1 has a score of less than or equal to
A4
B5
C6
D7
Show Answer & Explanation ▾
✓ Correct Answer: C. 6
Gleason system stratifies prostate cancer into 5 grades on basis of glandular patterns of growth. Grade 1 corresponds to well-differentiated tumors and grade 5 to poorly differentiated tumors. Most tumors contain more than one pattern, in these cases a primary grade is assigned to the dominant pattern, and a secondary grade is assigned to the second most frequent pattern. Gleason grade groups Group 1: score less than equal to 6 Group 2: 3 + 4 Group 3: 4 + 3 Group 4: 4 + 4/3 + 5/5 + 3 Group 5: 4 + 5/5 + 4/5 + 5 Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 977
Sample MCQ #8
Components of testicular dysgenesis syndrome are all except
ATesticular GCTs
BCryptorchidism
CEpispadias
DPoor sperm quality
Show Answer & Explanation ▾
✓ Correct Answer: C. Epispadias
Hypospadias is a component, not epispadias. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
What you can practise in Male Genital Tract
32 Male Genital Tract MCQs on Genitourinary System — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
Progress and performance tracking to measure retention
Male Genital Tract MCQs cover germ cell neoplasia in situ and its markers, from PLAP-positive seminoma to OCT3/4 embryonal carcinoma, isochromosome 12p, prostate ETS rearrangements, and Gleason grading. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
How many Male Genital Tract questions are there, and which exams do they cover?
MedLadder includes 32 curated MCQs for Male Genital Tract under Pathology (Genitourinary System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
