Skin Malignancies MCQs

Congenital melanocytic nevi are classified according to their estimated adult size as small (less than 1.5 cm), medium (1.5 to 20 cm), large (20 to 40 cm), and giant (>40 cm). This classification is essential as the size of nevi is one of the main risk factors of melanoma development and neurological involvement. CMNs frequently present with a garment appearance (in a bathing trunk, in coat sleeve, Reference: Rooks textbook of dermatology, chapter 143, page 143.2

This is the most common variant of primary CTCL; it is generally associated with an indolent clinical course Mycosis fungoides is characterized by polymorphic patches and plaques usually involving limb/girdle sites, the breast and especially the buttock area. The histological hallmark of the mycosis fungo ides is the presence of the Sezary-Lutzner cells. These are CD4 helper T cells. Reference: Rooks textbook of dermatology, chapter 140, page 140.1

Mycosis fungoides is an indolent cutaneous T-cell lymphoma (indolent course. but is inevitably fatal (not easily amenable to treatment), except for patients in stage I. MF is the most common primary cutaneous lymphoma. Pautrier microabscess is characteristic of MF. Erythroderma can occur in MF (Sezary syndrome) Reference: Rooks textbook of dermatology, chapter 140, page 140.10

Characteristic microscopic finding in sarcoidosis: Discrete, compact, non-caseating epithelioid cell granuloma' CD4+, CD8+ T lymphocytes and, to a lesser extent, B lymphocytes form a concentric rim around the epithelioid granuloma Reference: Rooks textbook of dermatology 9 th edition, chapter 98, page 3

Actinic keratosis or solar keratosis are a reflection of abnormal skin cell development due to exposure to ultraviolet radiation. Reference: Rooks textbook of dermatology, chapter 142, page 142.1

Actinic keratosis/Solar keratosis/ Keratosis senilis - Actinic keratoses are premalignant cutaneous lesions that may progress to squamous cell carcinoma. These lesions commonly appear on sun-exposed areas of the skin in individuals with a history of cumulative sun exposure. Common locations for actinic keratoses include the face, scalp (bald or thinning hair), back of the arms, and dorsal aspect of the hands. individuals with actinic keratosis may present with irregular, red, scaly papules or plaques on sun-exposed regions of the body The primary histopathologic feature of actinic keratosis is the presence of atypical keratinocytes(dyskeratotic cells)within sun-damaged skin that is limited to the lower third of the epidermis Reference: Rooks textbook of dermatology, chapter 142, page 142.2

Total Skin Electron Radiation is used primary in patients with Mycosis Fungoides. Reference: Rooks textbook of dermatology, chapter 140, page 140.22

The median age for the development of their first non-melanoma skin cancer is about 9. The common skin cancers in XP patients include Basal cell carcinomas (BCC)Squamous cell carcinomas (SCC), keratoacanthoma-SCC type and malignant melanoma Given the wide variation of clinical presentation of various skin cancers, patients with xeroderma pigmentosum must be followed closely for regular total body skin exams by a dermatologist. The mainstay of management is the avoidance of UVR exposure from sunlight through the application of high-factor sunscreen