Mixed / Miscellaneous Topics MCQs

Ans. is 'd' i.e., It is excreted primarily in urine Sunitinib inhibits multiple Tyrosine kinase receptors. It inhibits PDGF, VEGF and c-kit. o Sunitinib and sorafinib are used in renal cell carcinoma (in RCC there is overexpression of VEGF) and GIST (in GIST there is over expression of C-Kit & PDGF). o It is eliminated primarily by hepatic route with excretion in faeces.

Ans. is 'a' i.e., Neisseria meningitidis om

Ans. is 'c' i.e., Philadelphia chromosome is positive Juvenile CML is mostly seen in children below 2 years of age. Philadelphia chromosome is negative and leukocyte count is less than 100'000/mm3. Features Adult CML Juvenile CML Age 10-12 years 100'000 < 100'000 WBC type Granulocyte Monocyte Normoblastic Unusual Common HbF Normal Increased Immunoglobulins Normal Increased Muramidase levels Normal Increased Response to Busulphan Good Poor Survival 2.5-3 years 9 months

Answer- A. 5 gm/kg/day In malnourish child if there > 10 gm/kg/day = good weight gain 5-10 gm/kg/day = moderate weight gain < 5 gm/kg/day = poor weight gain

Ans. is 'a' i.e., Deficiency of C1 inhibitor Hereditary angioneurotic edema is due to C1inhibitor (Ci esterase inhibitor) deficiency.