Interleukins, Growth Factors and Targeted Therapies MCQs
Interleukins, Growth Factors and Targeted Therapies is part of the Anti-Neoplastic Agents section of Pharmacology. Practise 16 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
About Interleukins, Growth Factors and Targeted Therapies MCQs
Interleukins, Growth Factors and Targeted Therapies MCQs cover pegfilgrastim after myelosuppressive chemotherapy, erythropoietin in chronic renal insufficiency and stem cell support in relapsed breast cancer. These high-yield NEET PG questions on haematopoietic growth factors.
Sample Interleukins, Growth Factors and Targeted Therapies MCQs with answers
Sample MCQ #1
A 68-year-old woman had a relapse of breast cancer. The cancer was now unresponsive to standard doses of chemotherapy. The decision was made to treat the patient with high-dose chemotherapy followed by autologous stem cell transplantation. Which of the following drugs is needed for the patient's autologous stem cell transplantation?
AFilgrastim (G-CSF)
BFolic acid
CIntrinsic factor
DOprelvekin (interleukin-11)
Show Answer & Explanation ▾
✓ Correct Answer: A. Filgrastim (G-CSF)
The success of transplantation with peripheral blood stem cells depends on infusion of adequate numbers of hematopoietic stem cells. Administration of G-CSF to the donor (in the case of autologous transplantation, the patient who also will be the recipient of the transplantation) greatly increases the number of hematopoietic stem cells harvested from the donor’s blood. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 842-43
Sample MCQ #2
Which of the following statements about pegfilgrastim is true?
AIt decreases the risk of neutropenia in patients on anti- cancer therapy
BIt is a short acting drug
CIt can be given orally
DIt is recombinant GM CSF
Show Answer & Explanation ▾
✓ Correct Answer: A. It decreases the risk of neutropenia in patients on anti- cancer therapy
Filgrastim It is a recombinant human granulocyte-colony stimulating factor (G-CSF). Started one day after myelosuppressive chemotherapy and injected s.c. or i.v. (5 μg/kg) daily, till neutrophil count normalizes, may be used to shorten recovery time from neutropenia. It is a long acting drug due to its pegylated form. It is administered as parenterally(S/C or IV) MOA: Recombinant G CSF drug Uses: Neutropenia in HIV Myelodysplasia Chemotherapy induced agranulocytosis Aplastic anemia S/E: Bone pain Recombinant GM CSF drug: Sargramostim
Sample MCQ #3
Which of the following is most likely to be required by a 5-year-old boy with chronic renal insufficiency?
ACyanocobalamin
BErythropoietin
CFilgrastim (G-CSF)
DOprelvekin (IL-11)
Show Answer & Explanation ▾
✓ Correct Answer: B. Erythropoietin
The kidney produces erythropoietin; patients with chronic renal insufficiency often require exogenous erythropoietin to avoid chronic anemia. Reference: Basic & Clinical Pharmacology, Fourteenth Edition by Bertram G. Katzung Pg no. 887-89
What you can practise in Interleukins, Growth Factors and Targeted Therapies
16 Interleukins, Growth Factors and Targeted Therapies MCQs on Interleukins, Growth Factors, Targeted Therapies — each with detailed explanations
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What do Interleukins, Growth Factors and Targeted Therapies MCQs cover?
Interleukins, Growth Factors and Targeted Therapies MCQs cover pegfilgrastim after myelosuppressive chemotherapy, erythropoietin in chronic renal insufficiency and stem cell support in relapsed breast cancer. These high-yield NEET PG questions on haematopoietic growth factors.
How many Interleukins, Growth Factors and Targeted Therapies questions are there, and which exams do they cover?
MedLadder includes 16 curated MCQs for Interleukins, Growth Factors and Targeted Therapies under Pharmacology (Anti-Neoplastic Agents), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
