Non Hodgkin Lymphomas: High Grade is part of the Hematology section of Pathology. Practise 8 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Non Hodgkin Lymphomas: High Grade MCQs contrast Burkitt lymphoma, with its c-myc translocation and jaw tumours in children, against testicular lymphoma of older men and its tendency to reach the central nervous system. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
Testicular lymphoma is most common testicular neoplasm in men >60yrs age and have a propensity for CNS metastasis. Reference: Robbins & Cotran Pathologic Basis of Diseases 10 th edition, Chapter - 21 pg 969
Translocation between the c-myc gene and immunoglobulin genes is the defining feature of a Burkitt lymphoma. In 80% of cases the translocation, t(8;14), is between c-myc and the immunoglobulin heavy chain gene. The remainder of the cases involve translocation of c-myc with immunoglobulin light chain genes. Epstein-Barr virus is involved in almost all cases of African (endemic) Burkitt lymphoma, but fewer than 30% of sporadic or immunodeficiency related cases. This malignancy has one of the highest turnover rates known, making it extremely fast growing but also very chemo sensitive. Because of this fact, the risk of tumor lysis syndrome is very high. The neoplastic cells in Burkitt lymphoma do not express terminal deoxynucleotidyl transferase (TdT), distinguishing it from acute lymphoblastic leukemia. Reference : Robbins, 10 th edition, page number - 471
Non Hodgkin Lymphomas: High Grade MCQs contrast Burkitt lymphoma, with its c-myc translocation and jaw tumours in children, against testicular lymphoma of older men and its tendency to reach the central nervous system. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
MedLadder includes 8 curated MCQs for Non Hodgkin Lymphomas: High Grade under Pathology (Hematology), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
