Lung Tumors is part of the Respiratory System section of Pathology. Practise 16 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Lung Tumors MCQs sort lung cancers by immunohistochemistry, from TTF-1 and napsin A adenocarcinoma to p40-positive squamous carcinoma, and tie small cell carcinoma to hyponatraemia and squamous tumours to hypercalcaemia. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
Sample Lung Tumors MCQs with answers
Sample MCQ #1
A 62-year-old male patient presents with increasing chest pain, bloody sputum, and weight loss over the past 3 months. An HRCT scan reveals a mass, circumscribing the right main bronchus protruding into its lumen. Endobronchial lung biopsy was taken, based on the histopathological findings diagnosis of carcinoid tumor was given. All of the below mentioned IHC markers will shows, positivity in this tumor except:
ANSE
BSynaptophysin
CChromogranin
Dp40
Show Answer & Explanation ▾
✓ Correct Answer: D. p40
Specific markers associated with adenocarcinoma (TTF-1, napsin A) or squamous cell carcinoma (p40, p63), neuroendocrine tumor (Synaptophysin, NSE, chromogranin). Reference: Robbins 10th Ed, pg 719
Sample MCQ #2
A 63-year-old male patient having smoking history presented with shortness of breath and hemoptysis since 4 months. He is also complaining of productive cough and chest pain. Chest X-ray performed shows small mass in the right lung in the periphery. A transbronchial lung biopsy was performed and diagnosis of adenocarcinoma was made. Which IHC marker will be used to confirm the diagnosis?
Ap63
BNapsin A
CSynaptophysin
DPanCK
Show Answer & Explanation ▾
✓ Correct Answer: B. Napsin A
Specific markers associated with adenocarcinoma (TTF1, napsin A) or squamous cell carcinoma (p40, p63), neuroendocrine tumor (Synaptophysin, NSE). Reference: Robbins 10th Ed, pg 719
Sample MCQ #3
A 63-year-old female with an 80-pack-per year smoking history has been complaining of weakness and constipation. She also has abdominal pain and episodes of seizure. Laboratory testing reveals a total calcium of 13.0 mg/dL. On chest X-ray, she has a probable mass in the left upper lobe of the lung near the hilum. Of the following, what would a biopsy of the mass most likely reveal?
ANeoplastic glands
BSmall neoplastic cells with a high nuclear to cytoplasm ratio
CKeratin pearls
DNoncaseating granulomas
Show Answer & Explanation ▾
✓ Correct Answer: C. Keratin pearls
The patient has symptoms consistent with hypercalcemia: weakness, constipation, abdominal pain, and psychiatric symptoms. Seizures can also occur. Squamous cell carcinoma, which has keratin pearls, can produce a parathyroid-hormone-like protein that will result in hypercalcemia (C). Adenocarcinoma (A) and small cell carcinoma (B) are not usually associated with PTH production. The mass is not a pulmonary sarcoidosis (D). Reference: Robbins Basic Pathology, 10 th ed, Pg-539
Sample MCQ #4
A patient is brought to the emergency room following a seizure. Serum Na+ level is 128 mEq/L. The urine osmolarity is higher than serum osmolarity. Chest X-Ray reveals a centrally located lung mass. On biopsy it shows salt and pepper appearance. Which tumour is most likely present in view of the clinicopathological profile?
AAdenocarcinoma
BSquamous cell carcinoma
CMesothelioma
DSmall cell carcinoma
Show Answer & Explanation ▾
✓ Correct Answer: D. Small cell carcinoma
Until recently, carcinomas of the lung were classified into two broad groups: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), the latter including adenocarcinoma, squamous and large cell carcinoma, and large cell neuroendocrine carcinomas. Small cell lung carcinomas (SCLCs) generally appear as pale gray, centrally located masses that extend into the lung parenchyma. These cancers are composed of relatively small tumor cells with a round to fusiform shape, scant cytoplasm, and finely granular chromatin with a salt and pepper appearance. Reference: Robbins Basic Pathology, 10 th ed, Pg-539-540
Sample MCQ #5
A 63-year-old male chronic smoker patient presented with respiratory difficulties these days which usually gradually increasing since 2 months. Chest X-ray and CT scan show a mass in the periphery of left lung. Transbronchial lung biopsy was performed and based the histopathological features diagnosis of small cell carcinoma was given. To confirm your diagnosis which IHC will show positive expression?
Ap40
BTTF-1
CNSE
Dp63
Show Answer & Explanation ▾
✓ Correct Answer: C. NSE
Specific markers associated with adenocarcinoma (TTF-1, napsin A) or squamous cell carcinoma (p40, p63), neuroendocrine tumor, small cell carcinoma (Synaptophysin, NSE). Reference: Robbins 10th Ed, pg 719
Sample MCQ #6
Orphan annie eye nuclei appearance is characteristic of -
APapillary carcinoma thyroid
BCarcinoma pituitary
CParaganglioma
DMeningioma
Show Answer & Explanation ▾
✓ Correct Answer: A. Papillary carcinoma thyroid
Ans. is 'a' i.e., Papillary carcinoma thyroid o The nuclei of papillary carcinoma cells contain finely dispersed chromatin, which imparts an optically clear or empty appearance, giving rise to the designation ground glass or Orphan Annie eye nuclei.
What you can practise in Lung Tumors
16 Lung Tumors MCQs on Respiratory System — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
Progress and performance tracking to measure retention
Lung Tumors MCQs sort lung cancers by immunohistochemistry, from TTF-1 and napsin A adenocarcinoma to p40-positive squamous carcinoma, and tie small cell carcinoma to hyponatraemia and squamous tumours to hypercalcaemia. These are high-yield NEET PG questions for FMGE, INI-CET and NEET SS.
How many Lung Tumors questions are there, and which exams do they cover?
MedLadder includes 16 curated MCQs for Lung Tumors under Pathology (Respiratory System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
