Renin-Angiotensin-Aldosterone System is part of the Cardiovascular System section of Pharmacology. Practise 30 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Renin-Angiotensin-Aldosterone System MCQs examine sacubitril neprilysin inhibition, ACE inhibitor use in diabetic kidney disease and post-infarction remodelling. This high-yield NEET PG revision on blocking the RAAS axis at every level.
Sample Renin-Angiotensin-Aldosterone System MCQs with answers
Sample MCQ #1
What is the mechanism of action of Sacubitril?
AACE inhibitor
BNeutral endopeptidase inhibitor
CEndothelin antagonist
DAngiotensin receptor blocker
Show Answer & Explanation ▾
✓ Correct Answer: B. Neutral endopeptidase inhibitor
Sacubitril: It is an orally active Neutral Endopeptidase(NEP) inhibitor which increases the blood levels of Natriuretic Peptides and other vasodilator peptides resulting in natriuresis, diuresis, vascular relaxation, lowering of AngII as well as aldosterone levels. Combined with Valsartan, it affords symptomatic improvement in CHF patients. Option A: ACE inhibitors: Captopril, Lisinopril etc. Option C: Endothelin antagonist: Ambrisentan, Macitentan etc. Option D: Angiotensin receptor blocker: Valsartan, Telmisartan etc.
Sample MCQ #2
A 58-year-old female with diabetes with microalbuminuria, is started on captopril. What effect does a competitive inhibitor have on enzyme kinetics?
ADecreases Km
BDecreases Vmax
CIncreases Km
DIncreases Vmax
Show Answer & Explanation ▾
✓ Correct Answer: C. Increases Km
Reference: Basic & Clinical Pharmacology by Bertram G. Katzung Fourteenth Edition Pg no. 21
Sample MCQ #3
A 78-year-old woman presents with increasing shortness of breath since 3 months. She underwent an emergency PCI for myocardial infarction 12 months ago. At the time of discharge, EDV was 300 mL and ejection fraction was 58%. She admits to rarely taking her medication as she usually feels well and has no symptoms. Current Echocardiography shows left ventricular dilation and an end-diastolic volume of 390 mL; Ejection fraction is 35%. Which of the following is most likely to have prevented this patient's worsening of ventricular function?
AEnalapril
BAtorvastatin
CAbciximab
DNifedipine
Show Answer & Explanation ▾
✓ Correct Answer: A. Enalapril
This woman did not adhere to medical therapy after the myocardial infarction and presents with dyspnea on exertion and a reduced ejection fraction with left ventricular dilation. These findings are most likely the result of unhindered cardiac remodelling. ACE inhibitors such enalapril have been found to decrease remodelling by slowing down the rate of left ventricular dilation after acute myocardial infarction (MI). This effect is achieved by decreasing preload and after-load due to blockage of angiotensin II. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 222
What you can practise in Renin-Angiotensin-Aldosterone System
30 Renin-Angiotensin-Aldosterone System MCQs on Cardiovascular System — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
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What do Renin-Angiotensin-Aldosterone System MCQs cover?
Renin-Angiotensin-Aldosterone System MCQs examine sacubitril neprilysin inhibition, ACE inhibitor use in diabetic kidney disease and post-infarction remodelling. This high-yield NEET PG revision on blocking the RAAS axis at every level.
How many Renin-Angiotensin-Aldosterone System questions are there, and which exams do they cover?
MedLadder includes 30 curated MCQs for Renin-Angiotensin-Aldosterone System under Pharmacology (Cardiovascular System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
