Opioid Antagonists is part of the Central and Peripheral Nervous System section of Pharmacology. Practise 8 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
Opioid Antagonists MCQs centre on naloxone, naltrexone and nalmefene as pure antagonists, with questions on reversing opioid toxicity and dyspnoea relief in pulmonary oedema. This high-yield NEET PG revision on when antagonism helps and when it harms.
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The relief produced by intravenous morphine in dyspnea from pulmonary edema associated with left ventricular heart failure is remarkable. Proposed mechanisms include reduced anxiety ( perception of shortness of breath) and reduced cardiac preload (reduced venous tone) and afterload (decreased peripheral resistance). However, if respiratory depression is a problem, furosemide may be preferred for the treatment of pulmonary edema. On the other hand, morphine can be particularly useful when treating painful myocardial ischemia with pulmonary edema. Reference: LANG’ Basic & clinical pharmacology by Bertram G. Katzung, Susen B. Masters and Anthony J. Trevor 12 th edition. Chapter 31- Opioid Analgesics & Antagonists by Dr. Mark A. Schumacher,PhD,MD, Dr. Alan I. Basbaum,PhD,& Dr. Walter L. Way,MD. Page no. 553
Cardiovascular system- Most opioids have no significant direct effects on the heart and, other than bradycardia, no major effects on cardiac rhythm. Meperidine is an exception to this generalization because its antimuscarinic action can result in tachycardia. Anterolateral wall MI leads to Tachycardia and Hypertension. Most of the opioids causes but Meperidine causes tachycardia so it cannot be used. Reference : LANG’ Basic & clinical pharmacology by Bertram G. Katzung, Susen B. Masters and Anthony J. Trevor 12 th edition. Chapter 31- Opioid Analgesics & Antagonists by Dr. Mark A. Schumacher,PhD,MD, Dr. Alan I. Basbaum,PhD,& Dr. Walter L. Way,MD. Page no. 551
The pure opioid antagonist drugs naloxone, naltrexone, and nalmefene are morphine derivatives with bulkier substituents at the N 17 position. These agents have a relatively high affinity for μ-opioid binding sites. They have lower affinity for the other receptors but can also reverse agonists at δ and κ sites. Reference: LANG’ Basic & clinical pharmacology by Bertram G. Katzung, Susen B. Masters and Anthony J. Trevor 12 th edition. Chapter 31- Opioid Analgesics & Antagonists by Dr. Mark A. Schumacher,PhD,MD, Dr. Alan I. Basbaum,PhD,& Dr. Walter L. Way,MD. Page no. 559
Opioid Antagonists MCQs centre on naloxone, naltrexone and nalmefene as pure antagonists, with questions on reversing opioid toxicity and dyspnoea relief in pulmonary oedema. This high-yield NEET PG revision on when antagonism helps and when it harms.
MedLadder includes 8 curated MCQs for Opioid Antagonists under Pharmacology (Central and Peripheral Nervous System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
