Tumors of Eye MCQs

This is a typical presentation of fungal corneal ulcer. The only fungus given in the option is fusarium. Reference: Parson’s diseases of the Eye-Chap 12 – Diseases of Cornea.

D/D of LEUCOCORIA France TRIP to C DR Fungal endophthalmitis Toxocariasis ROP Inflammatory cyclitic membrane PHPV Congenital cataract, coloboma, Coats's disease Dysplasia of retina Retinoblastoma Reference: leucocoria

Uveal melanoma is a malignant tumor arising from melanocytes in the uveal tract (iris, ciliary body, or choroid). It is the most common primary intraocular tumor in adults with an age-adjusted incidence of 6 per million. The choroid is the most common site involved and gives rise to 90% of uveal melanomas. Melanomas arising within the ciliary body comprise 7% and melanomas of the iris account for 2% There is a strong tendency for metastasis, particularly to the liver, and prognosis is poor when the tumor has disseminated. Reference: Kanski's Synopsis of Clinical Ophthalmology (Fourth edition) 2023, Page 322

MC cause of unilateral proptosis in children: orbital cellulitis MC cause of bilateral proptosis in children: Neuroblastoma > leukemia - chloroma(Acute Myeloid Leukemia) MC cause of proptosis in adults: Thyroid ophthalmopathy both unilateral and bilateral MC tumour of orbit in children: Dermoid MC benign orbital tumour in adults: Cavernous haemangioma MC primary malignant tumour of orbit in children: Rhabdomyosarcoma MC primary malignant intraocular tumour in children: Retinoblastoma MC primary malignant intraocular tumour in adults: Choroidal melanoma MC source of orbital metastasis: breast in females, lung in males MC orbital metastasis in children: Neuroblastoma MC lymphomas in orbit are Non Hodgkin lymphoma Reference: parson 21st edition pg 482

Radio + Chemo(as rhabdomyosarcomas are highly radiosensitive tumours) Reference: parson's 22/e section VI chapter 30 pg. 495 rhabdomyosarcoma Rx

β-Irradiation, either primary or after tumour excision, is the treatment of choice for conjunctival melanomas. Malignant lesions may become radioresistant, in which case the only effective treatment is wide excision with exenteration of the orbit and extensive reconstitution by skin grafting. Reference: Parson’s Diseases of the Eye-Edition 23-Chap 11-Diseases of the Conjunctiva

The uvea is the most common site for ocular metastasis. Within the uvea, 88% of metastases are to the choroid, followed by metastases to the iris (9%) and ciliary body (2%) Ocular or eye metastasis are usually from a breast cancer (in women) and lung cancer (in men). Other less common sites of origin include the prostate, the kidney, the thyroid, and gastrointestinal tract. Reference: Parson 21st edition pg 481

Optic nerve gliomas that are confined to the orbit can be observed, particularly if vision is good. Radiation is used if the tumor is unresectable because of chiasm or tract involvement and symptoms are progressing. Chemotherapy is effective in progressive chiasmal or hypothalamic gliomas and may avoid complications of radiation. Surgery may be used for progressive lesions expanding toward the chiasm. Reference: Kanski 8th edition/107