Extrapyramidal Syndromes and Movement Disorders MCQs
Extrapyramidal Syndromes and Movement Disorders is part of the Nervous System section of Medicine. Practise 57 exam-style MCQs for NEET PG, FMGE, INI-CET and NEET SS, each with the correct answer and a detailed explanation.
About Extrapyramidal Syndromes and Movement Disorders MCQs
Extrapyramidal Syndromes and Movement Disorders MCQs track levodopa from early Parkinson disease through dyskinetic jerks, postural hypotension and visual hallucinations to rescue therapy for off-period akinesia, a sequence NEET PG and INI-CET examiners return to as high-yield neurology.
Sample Extrapyramidal Syndromes and Movement Disorders MCQs with answers
Sample MCQ #1
A patient with parkinsonism is being treated with levodopa. He suffers from irregular, involuntary muscle jerks that affect the proximal muscles of the limbs. Which of the following statements about these symptoms is most accurate?
ACoadministration of muscarinic blockers prevents the occurrence of dyskinesias during treatment with levodopa
BDrugs that activate dopamine receptors can exacerbate dyskinesias in a patient taking levodopa
CDyskinesias are less likely to occur if levodopa is administered with carbidopa
DThe symptoms are usually reduced if the dose of levodopa is increased
Show Answer & Explanation ▾
✓ Correct Answer: B. Drugs that activate dopamine receptors can exacerbate dyskinesias in a patient taking levodopa
The form and severity of dyskinesias resulting from levodopa may vary widely in individual patients. Dyskinesias occur in up to 80% of patients receiving levodopa for long periods. With continued treatment, dyskinesias may develop at a dose of levodopa that was previously well tolerated. Muscarinic receptor blockers do not prevent their occurrence. They occur more commonly in patients treated with levodopa in combination with carbidopa or with other dopamine receptor agonists. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 506-508
Sample MCQ #2
Extrapyramidal syndrome like side effects are seen in -
AHaloperidol
BClozapine
CTetracycline
DKetoconazole
Show Answer & Explanation ▾
✓ Correct Answer: A. Haloperidol
Ans. is 'a' i.e., Haloperidol Drugs causing extrapvramidal effects o Butyrophenones (Haloperidol) o Methyldopa o OCP'S o Reserpine o Levodopa o Metoclopromide o Phenothiazines o Tricyclic Antidepressants
Sample MCQ #3
A 38-year-old woman presents with slowed mentation, lack of coordination, and brief writhing movements of her hands that are not rhythmic with delusions. Her mother has had similar symptoms. Genetic testing shows mutation on chromosome 4. It is very likely that the most appropriate drug for treatment will be
AAmantadine
BBromocriptine
CLevodopa
DHaloperidol
Show Answer & Explanation ▾
✓ Correct Answer: D. Haloperidol
Although further diagnosis is desirable, choreo-athetosis with decreased mental abilities and psychosis (paranoia) suggests that this patient has the symptoms of Huntington’s disease. Drugs that are partly ameliorative include agents that deplete dopamine (eg, tetrabenazine) or that block dopamine receptors (eg, haloperidol). Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 509-511
Sample MCQ #4
A 53-year-old woman is started on a medication for early symptoms of Parkinson disease one week ago. Vital signs show blood pressure 120/70 mm Hg when supine and 90/60 mm Hg upon standing. Examination of the lower extremities shows a lacy, purple rash and 2+ pitting edema. The patient is most likely experiencing adverse effects caused by which of the following drug?
ASelegiline
BCarbidopa
CTolcapone
DAmantadine
Show Answer & Explanation ▾
✓ Correct Answer: D. Amantadine
This patient shows signs of amantadine toxicity, including orthostatic hypotension, livedo reticularis and peripheral edema. Amantadine can be used as initial short-term monotherapy in patients with mild symptoms of Parkinson disease, mainly for those with prominent tremor. In addition to the side effects seen in this patient, amantadine is associated with anticholinergic-like side effects (e.g., dry mouth, constipation), prolonged QT interval, and psychological disorders (e.g., hallucinations, anxiety). Reference: Basic & Clinical Pharmacology, Fourteenth Edition by Bertram G. Katzung Pg no. 500-508,512
Sample MCQ #5
A 72 years old woman complaints that sometimes she sees a dog in her kitchen and at other times she sees a snake in her garden, both of which no one else can see. She has Parkinson disease and is on treatment. Which of the following is the most likely underlying cause of this patient's symptoms?
ALevodopa
BCarbidopa
CTolcapone
DSafinamide
Show Answer & Explanation ▾
✓ Correct Answer: A. Levodopa
Levodopa (L-DOPA), a dopamine precursor, is the most effective medication for controlling the motor symptoms of Parkinson disease. Primary effects of L-DOPA are achieved by stimulating D2-receptors in the substantia nigra and striatum. However, overstimulation of D2-receptors by levodopa may also induce psychosis and hallucinations (usually visual). The risk for developing psychiatric symptoms increases with age, other psychiatric conditions, long duration of levodopa treatment, and high doses. Since this patient has been taking levodopa for 3 years and is elderly, her symptoms are most likely the result of levodopa therapy. Other adverse effects of L-DOPA therapy include dizziness, somnolence or insomnia, anxiety, and aggressive behavior. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 513
Sample MCQ #6
A 72-year-old man complains that he has had increased tremor and bradykinesia. He has started on levodopa, regarding side effects of the drug, the patient need not be informed that
AHe may feel dizziness, especially when in supine
BHe should take the drug in divided doses to avoid nausea
CHis symptoms will probably improve for a period of time but not indefinitely
DHe may feel uncontrollable muscle jerks.
Show Answer & Explanation ▾
✓ Correct Answer: A. He may feel dizziness, especially when in supine
In prescribing levodopa, the patient should be informed about adverse effects, including gastrointestinal distress, postural hypotension (dizziness while standing), and dyskinesias. It is reasonable to advise the patient that therapeutic benefits cannot be expected to continue indefinitely. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 502-503
Sample MCQ #7
A 51-year-old patient with parkinsonism is being maintained on levodopa-carbidopa with adjunctive use of low doses of tolcapone but continues to have off-periods of akinesia. A drug used to "rescue" the patient that provides temporary relief is
AApomorphine
BBenztropine
CPramipexole
DSelegiline
Show Answer & Explanation ▾
✓ Correct Answer: A. Apomorphine
Apomorphine, via subcutaneous injection, is used for temporary relief of off-periods of akinesia (rescue) in parkinsonian patients on dopaminergic drug therapy. Pretreatment with the antiemetic trimethobenzamide for 3 days is essential to prevent severe nausea. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 503-504
Sample MCQ #8
A 77-year-old patient with Parkinsonism is being maintained on levodopa-carbidopa but continues to have off-periods of akinesia. A subcutaneous injection is used to "rescue"the patient that provides temporary relief. With which of the following drug you will pretreat to prevent nausea?
AOndansetron
BDomperidone
CMetaclopromide
DTrimethobenzanide
Show Answer & Explanation ▾
✓ Correct Answer: D. Trimethobenzanide
Apomorphine, via subcutaneous injection, is used for temporary relief of off-periods of akinesia (rescue) in parkinsonian patients on dopaminergic drug therapy. Pretreatment with the antiemetic trimethobenzamide for 3 days is essential to prevent severe nausea. Reference: Basic & Clinical Pharmacology, Fourteenth Edition By Bertram G. Katzung Pg no. 503-504
What you can practise in Extrapyramidal Syndromes and Movement Disorders
57 Extrapyramidal Syndromes and Movement Disorders MCQs on Extrapyramidal Syndromes, Movement Disorders, Nervous System — each with detailed explanations
Previous-year question practice across NEET PG, FMGE, INI-CET and NEET SS
Progress and performance tracking to measure retention
What do Extrapyramidal Syndromes and Movement Disorders MCQs cover?
Extrapyramidal Syndromes and Movement Disorders MCQs track levodopa from early Parkinson disease through dyskinetic jerks, postural hypotension and visual hallucinations to rescue therapy for off-period akinesia, a sequence NEET PG and INI-CET examiners return to as high-yield neurology.
How many Extrapyramidal Syndromes and Movement Disorders questions are there, and which exams do they cover?
MedLadder includes 57 curated MCQs for Extrapyramidal Syndromes and Movement Disorders under Medicine (Nervous System), covering NEET PG, FMGE, INI-CET and NEET SS preparation.
